(Article en anglais seulement)

Leprosy and Crohn’s disease may share a common underlying genetic susceptibility related to nonspecific innate immunity, according to a genome-wide association study…. An attractive aspect of the study « is the apparently narrow focus of the genetic control, which highlights early antigen sensing and signaling in the pathogenesis of both leprosy and Crohn’s disease, » Erwin Schurr, Ph.D., and Philippe Gros, Ph.D., from McGill University in Montreal, write in an accompanying editorial. « It is tempting to speculate that these common genetic signatures support, albeit indirectly, the proposal that a proportion of Crohn’s disease cases may have a mycobacterial cause. »

Modern Medicine

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