(Article en anglais seulement)
Leprosy and Crohn’s disease may share a common underlying genetic susceptibility related to nonspecific innate immunity, according to a genome-wide association study…. An attractive aspect of the study «is the apparently narrow focus of the genetic control, which highlights early antigen sensing and signaling in the pathogenesis of both leprosy and Crohn’s disease,» Erwin Schurr, Ph.D., and Philippe Gros, Ph.D., from McGill University in Montreal, write in an accompanying editorial. «It is tempting to speculate that these common genetic signatures support, albeit indirectly, the proposal that a proportion of Crohn’s disease cases may have a mycobacterial cause.»
Modern Medicine
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